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KMID : 0043320140370070839
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Archives of Pharmacal Research
2014 Volume.37 No. 7 p.839 ~ p.844
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New eremophilane-type sesquiterpenes from an Antarctic deep-sea derived fungus, Penicillium sp. PR19 N-1
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Lin Aiqun
Wu Guangwei
Gu Qianqun
Zhu Tianjiao
Li Dehai
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Abstract
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Chemical investigation of an Antarctic deep-sea derived fungus Penicillium sp. PR19 N-1 yielded five new eremophilane-type sesquiterpenes 1?5 and a new rare lactam-type eremophilane 6, together with three known compounds 7?9. The structures of these diverse sesquiterpenes were determined by extensive NMR and mass spectroscopic analyses. Compounds 1, 2, 4?6, 8 and 9 were evaluated for their cytotoxities against HL-60 and A-549 human cancer cell lines, and 5 was the most active one with IC50 value of 5.2 μM against the A-549 cells.
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KEYWORD
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Eremophilane-type sesquiterpene, Antarctic deep-sea derived fungus, Penicillium sp.
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